Lehrveranstaltungen Lebenslauf Publikationen

Lehrveranstaltungen

Sommersemester 2024
Grundmodul Chemie für Biologen - Laborübungen [BIO-GM-C2] Laborpraktikum
Mastermodul Strukturbiologie - Seminar [BIO-MM-SB]
Mastermodul Strukturbiologie - Übung [BIO-MM-SB]
Mastermodul Strukturbiologie - Vorlesung [BIO-MM-SB]

Lebenslauf

Berufliche Erfahrungen

Seit Okt. 2020	Laborleiter und Dozent an der Universität Osnabrück, Gruppe Strukturbiologie von Prof. A. Möller
Sep. 2018 – Sep. 2020	Wissenschaftlicher Mitarbeiter an der Goethe-Universität Frankfurt am Main, IBCII, Gruppe Strukturelle Bioenergetik  von Prof. V. Zickermann
Dez. 2013 – Aug. 2018	Wissenschaftlicher Mitarbeiter am Max-Planck-Institut für Biophysik in Frankfurt/Main, Abt. Strukturbiologie von Prof. W. Kühlbrandt
Okt. 2011 – Dez 2013	Projektleiter an der Universität Regensburg am Lehrstuhl Biophysik II von Prof. C. Ziegler
Jan. 2011 – Sep. 2011	Post-Doktorand am Max-Planck-Institut für Biophysik in der Abteilung Molekulare Membranbiologie von Prof. H. Michel

Bildungshintergrund

Jul. 2022	Umhabilitation im Fach Mikrobiologie an der Universität Osnabrück
Jan. 2021	Habilitation im Fach Mikrobiologie an der Goethe-Universität Frankfurt am Main Mentor Prof. V. Müller
Juli 2007 – Feb. 2011	Doktorarbeit am Max-Planck-Institut für Biophysik in der Abteilung Molekulare Membranbiologie  von Prof. H. Michel
Okt. 2006 – Mai 2007	Diplomarbeit an der Universität Konstanz in der Arbeitsgruppe von Prof. P. M. H. Kroneck
Okt. 2001	Beginn des Diplom-Studiengang Biologie an der Universität Konstanz

Publikationen

(24) Gewering, T., Waghray, D., Parey, K., Zapata, J., Zhao, P., Chen, H., Januliene, D., Urbatsch, I.L., Moeller, A., and Zhang, Q. (2022), Mechanism of multimodal substrate translocation in P-glycoprotein. BioRxiv 

(23) Galazzo, L., Meier, G., Januliene, D., Parey, K., De Vecchis, D., Striednig, B., Hilbi, H., Schäfer, L.V., Kuprov, I., Moeller, A., Bordignon, E., Seeger, M.A.. (2022), The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells. Science advances, 8(41):eabn6845

(22) Moreno Chicano, T., Dietrich, L., de Almeida, N., Mohd, A., Hartmann, E., Leidreiter, F., Leopoldus, D., Müller, M., Sánchez, R., Nuijten, G., Reimann, G., Seifert, K. A., Schlichting, I., van Niftrik, L., Jetten, M. S. M., *Dietl, A., *Kartal, B., *Parey, K. and *Barends, T.R.M. (2021), Structural and functional characterization of the intracellular filament-forming nitrite oxidoreductase multiprotein complex, Nature Microbiology, 6(9):1129-1139

​​​​(21) Parey, K., Lasham, J., Mills, D.J., Djurabekova, A., Haapanen, O., Galemou Yoga, E., Xie, H. Kühlbrandt, W., Sharma, V., Vonck, J. and Zickermann, V. (2021), High-resolution structure and dynamics of mitochondrial complex I – insights into the proton pumping mechanism. Science advances, 12, eabj3221

(20) Yoga, E.G., Parey, K., Djurabekova, A., Haapanen, O., Siegmund, K., Zickermann, V., Sharma, V. and Angerer H. (2020), Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I. Nature Communications, 5, eaax9484

(19) Scherr, J., Tang, Z., Küllmer, M., Balser, S., Scholz, A.S., Winter, A., Parey, K., Rittner, A., Grininger, M., Zickermann, V., Rhinow, D., Terfort, A. and Turchanin, A. (2020), Smart molecular nanosheets for advanced preparation of biological samples in electron cryo-microscopy. ACS Nano, 14(8), 9972-9978

(18) Parey, K., Wirth, C., Vonck, J. and Zickermann, V. (2020), Respiratory complex I – structure, mechanism and evolution. Curr Opin Struc Biol, 63, 1-9

(17) Dasbach, M., Pyschik, M., Lehmann, V., Parey, K., Rhinow, D., Reinhardt, H.M. and Hampp, N.A. (2020), Assembling carbon nanotube architectures. ACS Nano, 14(7), 8181-8190

(16) Yoga, E.G., Angerer, H., Parey, K. and Zickermann, V. (2020), Respiratory complex I – Mechanistic insights and advances in structure determination. BBA Bioenergetics, 1861(3), 148153

(15) Parey, K., Haapanen, O., Sharma, V., Köfeler, H., Züllig, T., Prinz, S., Siegmund, K., Wittig, I., Mills, D.J., Vonck, J., Kühlbrandt, W. and Zickermann, V. (2019), High-resolution cryo-EM structures of respiratory complex I: mechanism, assembly and disease. Science advances, 5, eaax9484

(14) Scherr, J., Neuhaus, A., Parey, K., Klusch, N., Murphy, B.J., Zickermann, V., Kühlbrandt, W., Terfort, A. and Rhinow, D. (2019), Non-covalent functionalization of carbon substrates with hydrogels improves structural analysis of vitrified proteins by electron cryo-microscopy. ACS Nano, 13, 7185-7190

(13) Akram, M., Dietl, A., Mersdorf, U., Prinz, S., Maalcke, W., Keltjens, J., Ferousi, C., de Almeida, N., Reimann, J., Kartal, B., Jetten, M.S.M., *Parey, K. and *Barends, T.R.M. (2019), A 192-heme electron transfer network in the hydrazine dehydrogenase complex. Science advances, 5, eaav4310

(12) Parey, K., Brandt, U., Xie, H., Mills, D.J., Siegmund, K., Vonck, J., Kühlbrandt, W. and Zickermann, V. (2018), The cryo-EM structure of respiratory complex I at work. eLife, 7

(11) Scherr, J., Parey, K., Klusch, N., Murphy, B. J., Balser, S., Neuhaus, A., Zickermann, V., Kühlbrandt, W., Terfort, A. and Rhinow, D. (2017), Self-perforated hydrogel nanomembranes facilitate structural analysis of proteins by electron cryo-microscopy. ACS Nano 11(6), 6467-6473

(10) D´Imprima, E., Mills, D.J., Parey, K., Brandt, U., Kühlbrandt, W., Zickermann, V. and Vonck, D.J. (2016), CryoEM structure of respiratory complex I reveals a link to mitochondrial sulfur metabolism. BBA Bioenergetics, 1857(12), 1935-1942

(9) *Parey, K., Fielding, A.J.,Huber, H., and Ziegler, C. and *Rajendran, C. (2016), In meso crystal structure of a novel membrane-associated octaheme cytochrome c from the Crenarchaeon Ignicoccus hospitalis, FEBS J, 283(20), 3807-3820

(8) Hahn,A., Parey, K., Bublitz,M., Mills,D.J., Zickermann,V., Vonck, D.J., Kühlbrandt,W. and Meier,T. (2016), Structure of a complete mitochondrial ATP synthase dimer reveals molecular basis of inner membrane morphology. Mol Cell, 63(3), 445-456

(7) Fielding, A.J., Parey, K., Ermler, U., Scheller, S., Jaun, B. and Bennati, M. (2013), Advanced electron paramagnetic resonance on the catalytic iron-sulfur cluster bound to the CCG domain of heterodisulfide reductase and succinate: quinone reductase. J Biol Inorg Chem, 18(8), 905-991

(6) Parey, K., Demmer, U., Warkentin, E., Wynen, A., Ermler, U. and Dahl C. (2013), Structural, biochemical and genetic characterization of dissimilatory ATP sulfurylase from Allochromatium vinosum. PLoS One 8, (9) e74707

(5) Δ *Parey, K., Fritz, G., Ermler, U. and *Kroneck, P.M.H. (2013), Conserving energy with sulfate around 100 °C – structure and mechanism of key metal enzymes in hyperthermophilic Archaeoglobus fulgidus, Metallomics 5, 302-31

(4) Kaster, A.K., Moll, J., Parey, K. and Thauer, R.K. (2011), Coupling of ferredoxin- and reduction with H₂ via electron bifurcation in hydrogenotrophic methanogenic archaea. PNAS 108, 2981-2986

(3) Parey, K., Warkentin, E., Kroneck, P.M.H. and Ermler, U. (2010), Reaction cycle of the dissimilatory sulfite reductase from Archaeoglobus fulgidus. Biochemistry 49, 8912-8921

(2) Parey, K., Schiffer, A., Steuber, J., Ermler, U. and Kroneck, P.M.H. (2010), Dissimilatory sulfite reductase. Handbook of Metalloproteins, Editor: Albrecht Messerschmidt, John Wiley and Sons, Chichester, UK

(1) Schiffer, A., Parey, K., Warkentin, E., Diederichs, K., Huber, H., Stetter, K.O., Kroneck, P.M.H., and Ermler, U. (2008), Structure of the dissimilatory sulfite reductase from the hyperthermophilic Archaeon Archaeoglobus fulgidus. J Mol Biol 379, 1063-107