Lehrveranstaltungen Lebenslauf Publikationen

Lehrveranstaltungen

Sommersemester 2024
Mastermodul Genetik I: Seminar [BIO-MM-GE1] Aktuelle Themen der Genetik
Mastermodul Genetik I: Übungen [BIO-MM-GE1] Praktische Übungen mit Schwerpunkt Eukaryonten
Mastermodul Genetik II - Seminar [BIO-MM-GE2]
Mastermodul Genetik II - Übung [BIO-MM-GE2]
Mastermodul Genetik II - Vorlesung [BIO-MM-GE2]
Projektarbeit I/ Projektarbeit II - Genetik [BIO-PA-I/BIO-PA-II]
Seminar für Doktoranden, Bachelor- und Masterstudierende [BIO-S-DBM] - Bakterielle Phosphotransferase-Systeme
Seminar über Methoden der Genetik für Diplomanden und Doktoranden [in englischer Sprache] [BIO-S-DBM]
Spezialisierungsmodul: Literaturmodul - Genetik [BIO-LIT]

Lebenslauf

Studies and Profession:


1981-1988 Studies of Biology at the University of Osnabrück,
Diploma degree, grade 1,1

1988-1992 Ph.D. degree, University of Osnabrück
(Prof. J. W. Lengeler), grade „summa cum laude“

1993-1994 Research stay at the University of Utah, Salt Lake City,
financed by the Alexander von Humboldt–Foundation (Feodor Lynen Postdoc Research Program)

1994-1997 Post doc fellow at the University of Osnabrück
in the research program „Metabolic fluxes in microorganisms“ financed by the „Volkswagenstiftung“

1997-2003 Research assistant (C1) at the University of Osnabrück

1999-2010 Research project supervisor in the SFB 431 “Membrane proteins: Functional dynamics and their coupling to reaction chains”

2009-2012 Research project supervisor in the BMBF-FORSYS project "Metabolic balance in E. coli"

2003 Habilitation for Genetics

since 2003 Research assistant at the University of Osnabrück

since 2005 Coordinator of the "NaT-Working" project of the Biology department

since 2009 Scientific head of the Explain-OS (Experimentelles Lernlabor des Fachbereichs Biologie/Chemie der Universität Osnabrück)

2021-2023 Editor in Chief of the "LeLa magazin" (official journal of the LernortLabor Bundesverband)

Publikationen

List of publications


1. Jahreis, K., P. W. Postma, and Lengeler, J. W. (1991) Nucleotide sequence of the ilvH-fruR gene region of Escherichia coli K12 and Salmonella typhimurium. Mol. Gen. Genet. 226:332-326
2. Schmid, K., R. Ebner, K. Jahreis, J. W. Lengeler, and F. Titgemeyer. (1991) A sugar-specific porin, ScrY, is involved in sucrose uptake in enteric bacteria. Mol. Microbiol. 5, 941-950
3. Aulkemeyer, P., R. Ebner, G. Heilenmann, K. Jahreis, K. Schmid, S. Wrieden, and J. W. Lengeler. (1991) Molecular analysis of two fructokinases involved in sucrose metabolism of enteric bacteria. Mol. Microbiol. 5, 2913-2922
4. Jahreis K., and J. W. Lengeler. (1993) Molecular analysis of two ScrR repressors and of a ScrR-FruR hybrid repressor for sucrose and D-fructose specific regulons from enteric bacteria. Mol. Microbiol. 9, 195-209
5. Lengeler, J. W., Jahreis, K., and Wehmeier, U. F. (1994) Enzymes II of the phosphoenol pyruvate-dependent phosphotransferase systems: their structure and function in carbohydrate transport. Biochim. Biophys. Acta 1188,1-28
6. Lux, R. , Jahreis, K., Bettenbrock, K., Parkinson, J. S., and Lengeler, J. W. (1995) Coupling the phosphotransferase system and the methyl-accepting chemotaxis protein-dependent chemotaxis signaling pathways of Escherichia coli. Proc. Natl. Acad. Sci. USA,: 11583-11587
7. Lengeler, J. W., Jahreis, K., and Schmid, K. (1995). Hierachical regulatory networks and engineering of metabolic fluxes in the prokaryotes. Biochemical Engineering 3, 153-155
8. Titgemeyer, F., Jahreis, K., Ebner, R., and Lengeler, J. W. (1996) Molecular analysis of the scrA and scrB genes from Klebsiella pneumoniae and plasmid pUR400, which encode the sucrose transport protein Enzyme II^Scr of the phosphotransferase system and a sucrose-6-phosphate invertase. Mol. Gen. Genet. 250, 197-206
9. Lengeler, J. W., and Jahreis, K. (1996) Phosphotransferase systems or PTSs as carbohydrate transport and as signal transduction systems. Handbook of Biological Physics, Vol. 2. Ed. W. N. Konings, H. R. Kaback and J. S. Lolkema, 573-598
10. Hochhut, B., Jahreis, K., Lengeler, J. W., and Schmid, K. (1997) CTnscr94, a conjugative transposon found in Enterobacteria. J. Bacteriol. 179, 2097-2102
11. Lengeler, J. W., and K. Jahreis. (1997) Gentechnik- Probleme, Chancen, Risiken. Biologie in der Schule 46,184-195
12. Zeppenfeld, T., Larisch, C., Lengeler, J. W., and Jahreis, K. (2000) Glucose transporter mutants of Escherichia coli K-12 with changes in substrate recognition of IICBGlc and induction behavior of the ptsG gene. J. Bacteriol. 182, 4443-4452
13. Kremling, A., Jahreis, K, Lengeler, J. W., and Gilles, E. D. (2000) The organization of metabolic reaction networks: A signal-oriented approach to cellular models. Metabolic Engineering,1-11
14. Steward, R. C, Jahreis, K., Parkinson, J. S. (2000) Rapid phosphotransfer to CheY from a CheA protein lacking the CheY-binding domain. Biochemistry. 39, 13157-13165
15. Kremling, A., Bettenbrock, K., Laube, B., Jahreis, K, Lengeler, J. W., and Gilles, E. D. (2001) The organization of metabolic reaction networks III: Application for diauxic growth on glucose and lactose. Metabolic Engineering 3, 362-379
16. Wang, J., Gilles, E. D., Lengeler, J. W., and Jahreis, K. (2001) Modelling of inducer exclusion and catabolite repression based on PTS-dependent sucrose and non-PTS dependent glycerol transport systems in Escherichia coli K-12 and its experimental verification. J. Biotechnol. 92, 133-158
17. Jahreis, K. , Bentler, L., Bockmann, J., Hans, S., Meyer, A., Siepelmeyer, J., and Lengeler, J. W. (2002) Regulation of the sucrose metabolism of Escherichia coli wild type EC3132. J. Bacteriol. 184, 5307-5316
18. Held, M., Schumann, W., Jahreis, K., Schmidt, H.-L. (2002). Microbial biosensor array with transport mutants of Escherichia coli K-12 for the simultaneous determination of Mono- and Disaccharides. Biosens. Bioelectron. 17, 1089-1094
19. Kamionka, A., Parche, S., Nothaft, H., Siepelmeyer, J., Jahreis, K., and Titgemeyer, F. (2002) The phosphotransferase system of Streptomyces coelicolor: IIA^Crr exhibits properties that resemble transport and inducer exclusion function of IIA^Glucose of Escherichia coli. Eur. J. Biochem. 269, 2143-2150
20. Stein, A., Seifert, M., Volkmer-Engert, R., Siepelmeyer, J., Jahreis, K., and Schneider, E. (2002) Functional characterization of the maltose ATP-binding-cassette transporter of Salmonella typhimurium by means of monoclonal antibodies directed against the MalK subunit. Eur. J. Biochem 269, 4074-4085
21. Jahreis, K., Morrison, T. B., Garzon, A., and Parkinson, J. S. (2004) Chemotactic signalling by an Escherichia coli CheA mutant that lacks the binding for phosphoacceptor partners. J. Bacteriol.186, 2664-72
22. Bettenbrock, K., Fischer, S., Kremling, A., Jahreis, K., Sauter, T., Gilles, E.D. (2006) A quantitative approach to catabolite repression in Escherichia coli. J. Biol. Chem. 2812578-2812584; Epub 2005 Nov 1.
23. Becker, A.K., Zeppenfeld, T., Staab, A., Seitz, S., Boos, W., Morita, T., Aiba, H., Mahr, K., Titgemeyer, F., Jahreis, K. (2006) YeeI, a novel protein involved in modulation of the activity of the glucose-phosphotransferase system in Escherichia coli K-12. J. Bacteriol.188, 5439-5449
24. Pimentel-Schmitt, E. F., Thomae, A.W., Amon, J., Klieber, M., Roth, H., Muller, Y., Jahreis, K., Titgemeyer, F. (2007) A glucokinase from Mycobacterium smegmatis. J. Mol. Microbiol. Biotechnol. 12,73-79.
25. Bettenbrock, K., Sauter, T., Jahreis, K., Kremling, A., Lengeler, J.W. Gilles, E.D. (2007) Correlation between growth rates, EIIA^Crr phosphorylation, and intracellular cyclic AMP levels in Escherichia coli K-12. J Bacteriol. 2007 Oct;189(19):6891-900.
26. Pimentel-Schmitt, E. F., Jahreis, K., Eddy, M.P., Amon, J., Burkovski, A., Titgemeyer, F. (2009) Identification of a glucose permease from Mycobacterium smegmatis mc2 155. J Mol Microbiol Biotechnol 16, 169-175.
27. Jahreis, K., Pimentel-Schmitt, E. F., Brückner, R., Titgemeyer, F. (2008) Ins and outs of glucose transport systems in eubacteria. FEMS Microbiol Rev 32, 891-907
28. Lengeler, J.W., and Jahreis, K. (2009) Bacterial PEP-dependent Carbohydrate: Phosphotransferase Systems Couple Sensing and Global Control Mechanisms.Contrib Microbiol 16, 65-87
29. Becker, L., Nieberg, C., Jahreis, K., and Peters, E. (2009) MHC class II variation in the endangered European mink Mustela lutreola (L.1761) - consequences for species conservation. Immunogenetics 61, 281-288.
30. Jahreis, K. (2010) cAMP signaling in prokaryotes, in: Bacterial Signaling; edited by Reinhard Krämer and Kirsten Jung; WILEY-VCH Verlag, Weinheim; Chapter 20: 357-375.
31. Kaleta C, Göhler A, Schuster S, Jahreis K, Guthke R, and Nikolajewa S. (2010 )Integrative inference of gene-regulatory networks in Escherichia coli using information theoretic concepts and sequence analysis.BMC Syst Biol. 18;4:116-124.
32. Gabor E, Göhler AK, Kosfeld A, Staab A, Kremling A, and Jahreis K. (2011) The phosphoenolpyruvate-dependent glucose-phosphotransferase system from Escherichia coli K-12 as the center of a network regulating carbohydrate flux in the cell. Eur J Cell Biol. 9:711-20. Epub 2011 May 28.
33. Göhler AK, Kökpinar Ö, Schmidt-Heck W, Geffers R, Guthke R, Rinas U, Schuster S, Jahreis K, Kaleta C. (2011) More than just a metabolic regulator - elucidation and validation of new targets of the regulator PdhR in Escherichia coli. BMC Syst Biol. 5:197-208
34. Göhler AK, Staab A, Gabor E, Homann K, Klang E, Kosfeld A, Muus J-E, Wulftange JS, and Jahreis K. (2012) Characterization of MtfA, a novel regulatory output signal protein of the glucose-phosphotransferase system in E. coli K-12. J. Bacteriol.194(5):1024-1035.
35. Bettenbrock K, Jahreis K, Kremling A, Pfaff M, Rinas U, Schuster S and Guthke R. (2012) Das Bakterium Escherichia coli: Ein Modellorganismus für die Systembiologie. Systembiologie.de 4:84.86
36. Xu Q, Göhler AK, Kosfeld A, Carlton D, Chiu H-J, Klock HE, Knuth MW, Miller MD, Elsliger M-A, Deacon AM, Godzik A, Lesley SA, Jahreis K, and Wilson IA. Structure of Mlc Titration Factor A (MtfA/YeeI) Reveals a Prototypical Zinc Metallopeptidase Related to Anthrax Lethal Factor. J. Bacteriol. Jun;194(11):2987-99. Epub 2012 Mar 30.
37. Kosfeld, A. and Jahreis, K. (2012) Characterization of the interaction between the small regulatory peptide SgrT and the EIICB^Glc of the glucose-phosphotransferase system of E. coli K-12. Metabolites 2, 756-774; doi:10.3390/metabo2040756
38. Kremling, A., Goehler, A., Jahreis, K., Nees, M., Auerbach, B., Schmidt-Heck, W., Kökpinar, Ö., Geffers, R., Rinas, U., Bettenbrock, K.. Analysis and design of stimulus response curves in central metabolism of E. coli. Metabolites 2, 844-871;doi:10.3390/metabo2040844
39. Kreth, J., Lengler, J.W., and Jahreis, K. (2013) Characterization of Two Pyruvate Uptake Systems in Escherichia coli K-12. PLOS ONE 8(6):e67125, doi:10.1371

40. Durán-López, M.E., Caroca, R., Jahreis, K ., Narváez, M., Ansaloni, R., Cazar, M.E (2019) Ceratobasidium sp. and Sebacina vermifera as promoters of seed germination and seedling development of the terrestrial orchid Epidendrum secundum Jacq., growing in the Ecuadorian Andes. South African Journal of Botany 125, 54-61; doi.org/10.1016/s.sajb.2019.06.029